SPG 4 Denovo

Hereditary Spastic Paraplegia (SPG4 Denovo Arg499His)

Welcome to SPG4together — a dedicated space for families and individuals affected by Hereditary Spastic Paraplegia (HSP) due to the Arg499His mutation in the SPAST gene. This rare genetic variant, located on chromosome 2p22, is often poorly understood and underrepresented in broader HSP resources. This site exists to offer accurate information, emotional support, and a private community for sharing stories, resources, and strength. You’re not alone in this — and together, we can better understand the journey, one connection at a time.

We also welcome those of you who might be a patient with a different subtype of HSP and hope that the information presented might be useful to you as well during your journey.